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Peptide Medicine

Peptide Medicine

  • 分类:Departments
  • 发布时间:2020-02-26 00:00:00
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概要:
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The research progress

Technology

Chen, J.; Huang, Y.*, Asymmetric Catalysis with N-heterocyclic Carbenes as Non-covalent Chiral Templates. Nat. Commun. 2014, 5, 3437.

Yuan, P.; Chen, J.*; Zhao, J.*; Huang, Y.*, Enantioselective Hydroamidation of Enals by Trapping of a Transient Acyl Species. Angew. Chem. Int. Ed. 2018, 57, 8503.

Wang,Z.; Li, X.; Huang, Y.*, Direct α-Vinylidenation of Aldehydes and Subsequent Cascade Gold and Amine Catalysts Work Synergistically. Angew. Chem. Int. Ed. 2013, 42, 14219. Luo, C.;

Wang, Z.; Huang, Y.*, Asymmetric Intramolecular α-Cyclopropanation of Aldehydes Using a Donor/Acceptor Carbene Mimetic. Nat. Commun. 2015, 6, 10041.

Technology
Technology

Wang, L.; Wu, F.; Chen, J.; Nicewicz, D. A.*; Huang, Y.*, Visible Light Mediated [4+2] Cycloaddition of Styrenes Synthesis of Tetralin Derivatives. Angew. Chem. Int. Ed. 2017, 56, 6896.

Wu, F.; Wang, L.; Chen, J.*; Nicewicz, D. A.*; Huang, Y.*, Direct Synthesis of Polysubstituted Aldehydes via Visible-Light-Catalysis. Angew. Chem. Int. Ed. 2018, 57, 2174.

Wang, Z.; He, Z.; Zhang, L.; Huang, Y.*, Iridium-Catalyzed Aerobic α,β-Dehydrogenation of γ,δ-Unsaturated Amides and Acids: Activation of Both α- and β-C–H bonds through an Allyl–Iridium Intermediate. J. Am. Chem. Soc., 2018, 140, 735.

He, Z.; Song, F.; Sun, H.; Huang, Y.*, A Transition-Metal-Free Suzuki-Type Cross-Coupling Reaction of Benzyl Halides and Boronic Acids via 1,2-Metallate Shift. J. Am. Chem. Soc., 2018, 140, 2693.

Technology
Technology

Pan, P.; Chen, J. et al. Huang, Y.*; Hou, T.*, Structure-Based Drug Design and Identification of H2O-Soluble and Low Toxic Hexacyclic Camptothecin Derivatives with Improved Efficacy in Cancer and Lethal Inflammation Models in Vivo. J. Med. Chem. 2018, 61, 8613.

Pan, P.; Yu, H. et al. Huang, Y.*; Hou, T.*, Combating Drug-Resistant Mutants of Anaplastic Lymphoma Kinase with Potent and Selective Type‑I 1/2 Inhibitors by Stabilizing Unique DFG-Shifted Loop Conformation. ACS Cent. Sci. 2017, 3, 1208.

 

Polypeptide drugs:

The research group has 10 full-time researchers (team leader, associate researcher, postdoctoral fellow, assistant researcher, etc.), more than 20 postgraduates, with an average age of about 30 years old.
 
1. Leader of the research group
 
Li zigang, Ph.D., graduated from the university of science and technology of China (ustc) with a bachelor's degree in 2001. He received his doctorate in chemistry from the university of Chicago in 2008.In 2010, he returned to China and won the title of distinguished researcher of the "hundred talents plan" of Peking University. Currently, he is the doctoral supervisor and project leader of the chemical genomics major of Peking University.The research team is committed to the chemical and biological intersection of chemical solutions to biological problems.
 
Research areas include polypeptide engineering and microbial research, including the construction of the secondary structure methodology for stable polypeptides, the use of polypeptide drugs in important human diseases, and the development of antiviral polypeptides.In recent years, the journal Science Advances, Nature Chemical Biology, Cell Chemical Biology, Proc. Natl. Acad. Sci., j. Am. Chem. Soc., Angew. Chem. Int. Ed., j. Med. Chem., Chemical Science, CancerMore than 80 papers have been published in international top academic journals such as research and Chemical Reviews, and the research results have been featured on the cover of high-level magazines for many times, and have received extensive attention from international and domestic peers. Besides, it has carried out international cooperation on a number of innovative new drug technologies with multinational pharmaceutical companies such as Pfizer, bayer healthcare and roche China.
 
(1) research and work experience
1) 2010-present shenzhen graduate school of Peking University, project leader, doctoral supervisor
2) 2009-2010 Harvard University, department of chemistry and chemical biology, postdoctoral
3) 2004-2008, Ph.D., department of chemistry, university of Chicago
4) 2001-2004, master, department of chemistry, tulane university
5) 1996-2001, bachelor, department of neuroscience and biophysics, university of science and technology of China
 
(2) scientific research awards
 
The second prize of science and technology progress of shenzhen in 2018
2016 guangdong special support plan of leading talents
2013 chutian scholar chair professor in hubei province
2013 outstanding youth of shenzhen
2013 special commissioner for science and technology enterprises in guangdong province
2012 shenzhen overseas high-level talents
2011 high-level talents in shenzhen
2010 Peking University hundred plan
2009-2010 American cancer center postdoctoral fellowship
2008-2009 Harper doctoral dissertation fellowship, university of Chicago
 
2. Deputy leader of the research group, Yin feng
 
Dr. Yin feng, who graduated from Peking University in 2014 with a major in cell biology, has conducted in-depth research in the field of cancer and tumor stem cell epigenetics.From 2014 to 2015, he worked as a postdoctoral fellow at nanyang technological university in Singapore, where he studied the delivery system of cancer-targeted nanomaterials, and designed and developed a nano-silicon fluorescent probe targeting pancreatic cancer and a pancreatic cancer treatment complex using gold nanorods as gene/anticancer drug dual carrier.From 2016 to 2017, I worked as a postdoctoral fellow in professor li zigang's research group of shenzhen graduate school of Peking University, engaged in biomedical research on stable peptides and research on peptide delivery system. At the end of 2017, I served as an associate researcher, and designed and developed a series of stable peptide inhibitors with anti-cancer activity.In the past five years, I have applied for 7 patents (1 authorization) and published more than 40 articles in international academic journals (25 articles by the first author and corresponding author).They have been published in internationally renowned academic journals such as Cancer Research, Nano Letter, Material Horizons, Chemical Science, Coordination Chemistry Reviews, Theranostics, Advance Materials, Cell Reports, Chemistry Communication, etc.
 
(1) research and work experience
1) 2019 - present shenzhen bay laboratory, associate researcher
2) 2017-2019 associate research fellow, shenzhen graduate school, Peking University
3) 2015-2017 postdoctoral fellow, shenzhen graduate school, Peking University
4) 2014-2015, postdoctoral fellow, nanyang technological university, Singapore
5) 2009-2014, cell biology, Peking University, Ph.D
 
(2) scientific research awards
Top young talents of science and technology innovation in guangdong province
Shenzhen nanshan district pilot talents
2017 Peking University tsinghua university life science center (NLS) outstanding postdoctoral
2016 shenzhen overseas high-level talents

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