化学合成

Chemical synthesis:

Research direction: This research group proposed a new strategy of proton-shuttling catalysis (i.e. space regulation of protons) and realized a series of highly asymmetric reactions, and then designed multi-site catalytic intermediates to participate in the selective protonation (i.e. time regulation of protons) to unlock a series of unknown chemical reactions.On this basis, the concept of proton selective migration is applied to the migration reactions of other groups, which provides new ideas and technical means for the synthesis of important drug fragments and skeletons.Main research directions include :(1) development of proton migration reagent;(2) study on reactive intermediates at multiple sites;(3) study on group migration reaction;(4) research on the application of synthetic methodology to targeted antitumor drug chemistry.

The research team

Dr. Wong chung, senior research fellow   Winner of the national science foundation for outstanding young people   1997: bachelor of Beijing university 1998: master degree, university of Chicago 2002: Ph.D., university of Chicago 2002-2004: postdoctoral fellow, California institute of technology 2004-2009: senior research associate, Merck r&d center, USA 2009-present: professor, shenzhen graduate school, Peking University 2019 to present: professor, shenzhen bay laboratory

Dr. Jiean Chen, associate researcher 2010: bachelor of sun yat-sen university 2015: doctor of Peking University 2015-2017: postdoctoral fellow of Peking University 2017-2019: associate research fellow, shenzhen graduate school, Peking University 2019 to present: associate researcher, shenzhen bay laboratory